Endocrine Abstracts

Various criteria have been proposed to diagnose and treat gestational diabetes due to uncertainties about the influence of mild degrees of maternal glucose intolerance on pregnancy outcomes. We used receiver operating characteristics (ROC) curve analysis to correlate macrosomia (more than or equal to 4000g) with varying thresholds for the 2 hour 75 gm oral glucose tolerance test (OGTT) results in pregnant women screened at our hospital from 1998-2001.Wom...

Management of Thyrotoxicosis in a Non-compliant Pregnant WomanA 23-year-old woman with Grave's disease presented to thyroid clinic 29 weeks into her first pregnancy having recently moved into the area. She had failed to attend hospital thyroid clinics elsewhere and frequently changed her address.Despite propylthiouracil 300 mg daily she had marked tremor, tachycardia 100 bpm, ophthalmopathy, and a large smooth goitre. TSH <0.0...

Insulin resistance is associated with obesity, metabolic syndrome and hypertension. These risk factors for type 2 diabetes and cardiovascular disease may be programmed by the early diet. Previous studies have shown poor insulin sensitivity in obese relative to lean sheep. Here, we considered whether insulin sensitivity in pre- and postnatally nutritionally challenged sheep offspring was due to changes at the pancreatic level. Thirty-six twin-bearing ewes were randomly allocate...

Generalised resistance to glucocorticoid is a rare familial or sporadic disease with partial target tissue insensitivity to glucocorticoids. Compensatory activation of the hypothalamo–pituitary–adrenal axis occurs with raised andrenocorticotrophic (ACTH) hormone levels and increased synthesis of adrenal steroids. The phenotype varies from asymptomatic to excess glucocorticoid, mineralocorticoid and androgenic effects.A 20-year-old female was fo...